Although she's only sixteen and looks even younger, Misao Makimachi is already a skilled and competent member of the Oniwabanshu ninja clan. That's fortunate for Misao, because her onimitsu talents may be all that keeps her alive when a journey in search of the leader of the clan, Aoshi Shinomori, leads her instead into a face-to-face encounter with an even more dangerous man and a plot to overthrow the Meiji government! Quickly enmeshed in the affairs of the legendary assassin Hitokiri Battosai, now known as Kenshin Himura, wielder of the reverse-blade sword, Misao finds herself pulled into the middle of a deadly intrigue against Makoto Shishio, who is orchestrating the conquest of all Japan - beginning with Kyoto!
| Writing | Nobuhiro Watsuki | Original Story |
| Production | Ai Abe | Producer |
| Production | Keiichi Matsuda | Producer |
| Directing | Kazuhiro Furuhashi | Director |
| Editing | Masahiro Matsumura | Editor |
| Writing | Mari Okada | Writer |
| Writing | Mari Okada | Series Composition |
| Visual Effects | Hiromitsu Hagiwara | Character Designer |
| Art | Ken Naito | Art Direction |
| Art | Kazuhiro Ito | Art Designer |
| Visual Effects | Shinji Matsumoto | Color Designer |
| Camera | Shinichi Igarashi | Director of Photography |
| Production | Hideo Katsumata | Production Designer |
| Visual Effects | Hiromitsu Hagiwara | Animation Director |
| Sound | Noriyuki Asakura | Music |
| Sound | Yuji Mitsuya | ADR Supervisor |
| Art | Kazuhiro Furuhashi | Storyboard Artist |
| Art | Hiro Kaburagi | Storyboard Artist |
| Visual Effects | Hiro Kaburagi | Animation Technical Director |
| Visual Effects | Masaaki Kannan | Animation Supervisor |
| Visual Effects | Yuki Iwai | Animation Supervisor |
| Visual Effects | Tokuyuki Matsutake | Animation Supervisor |
| Visual Effects | Masao Ebihara | Key Animation |
| Visual Effects | Manabu Akita | Key Animation |
| Visual Effects | Hanako Enomoto | Key Animation |
| Visual Effects | Haruyo | Key Animation |
| Visual Effects | Hitomi Hasegawa | Key Animation |
| Visual Effects | Tomomi Ikeda | Key Animation |
| Visual Effects | Youichi Ishikawa | Key Animation |
| Visual Effects | Jeong Yeong-hoon | Key Animation |
| Visual Effects | Takashi Kojima | Key Animation |
| Visual Effects | Tomochi Kosaka | Key Animation |
| Visual Effects | Masayuki Kouda | Key Animation |
| Visual Effects | Emi Kouno | Key Animation |
| Visual Effects | Toshimasa Kuroyanagi | Key Animation |
| Visual Effects | Kanae Matsunaga | Key Animation |
| Visual Effects | Rumi Miyata | Key Animation |
| Visual Effects | Emiko Momose | Key Animation |
| Visual Effects | Toshiharu Murata | Key Animation |
| Visual Effects | Atsuko Nakajima | Key Animation |
| Visual Effects | Rui Niitsuma | Key Animation |
| Visual Effects | Mayumi Oda | Key Animation |
| Visual Effects | Eri Sano | Key Animation |
| Visual Effects | Tomoko Sugimoto | Key Animation |
| Visual Effects | Kazuma Uike | Key Animation |
| Visual Effects | Misao Abe | Key Animation |
| Visual Effects | Takahito Katayama | Key Animation |
| Visual Effects | Aika Kawasaki | Key Animation |
| Visual Effects | Yui Kinoshita | Key Animation |
| Visual Effects | Tomoyuki Kitamura | Key Animation |
| Visual Effects | Erina Kojima | Key Animation |
| Visual Effects | Ryou Komori | Key Animation |
| Visual Effects | Yumi Nakayama | Key Animation |
| Visual Effects | Fuminori Tsukida | Key Animation |
| Visual Effects | Takenori Tsukuma | Key Animation |
| Visual Effects | Yuko Yamada | Key Animation |
| Visual Effects | Risako Yoshida | Key Animation |
| Sound | Yuika Shiraishi | Sound Designer |
| Sound | Minoru Yamada | Sound Designer |
| Editing | Yuki Koike | Assistant Editor |
| Production | Nobuyasu Nobe | Production Manager |
| Production | Takuma Hirabayashi | Assistant Production Manager |
| Sound | Rina Sumioka | Theme Song Performance |
| Sound | Noriyuki Asakura | Main Title Theme Composer |
| Crew | Takeshi Saito | Special Effects |
