Having lost their status and credibility five years after covering New York City with gooey roasted marshmallows in Ghostbusters (1984), the city's former heroes and once-popular spirit-hunters struggle to keep afloat, forced to work odd jobs. However, when Dana and her baby have yet another terrifying encounter with the paranormal, it is up to Peter Venkman and his fearless team of supernatural crime fighters to step up and save the day. Once more, humankind is in danger, as rivers of slimy psycho-reactive ectoplasm, paired with the dreadful manifestation of evil sixteenth-century tyrant Vigo the Carpathian, threaten to plunge the entire city into darkness. Is the world ready to believe? Can the Ghostbusters save us for the second time?
| Directing | Ivan Reitman | Director |
| Production | Ivan Reitman | Producer |
| Writing | Dan Aykroyd | Screenplay |
| Writing | Harold Ramis | Screenplay |
| Crew | Danny Aiello III | Stunts |
| Sound | Randy Edelman | Original Music Composer |
| Camera | Michael Chapman | Director of Photography |
| Editing | Donn Cambern | Editor |
| Editing | Sheldon Kahn | Editor |
| Production | Michael Chinich | Casting |
| Art | Bo Welch | Production Design |
| Art | Tom Duffield | Art Direction |
| Art | Cheryl Carasik | Set Decoration |
| Costume & Make-Up | Gloria Gresham | Costume Design |
| Costume & Make-Up | Stephen Abrums | Makeup Artist |
| Costume & Make-Up | Gandhi Bob Arrollo | Makeup Artist |
| Costume & Make-Up | Frank Bianco | Hairstylist |
| Costume & Make-Up | John M. Elliott Jr. | Key Makeup Artist |
| Costume & Make-Up | Peggy Semtob | Hairstylist |
| Costume & Make-Up | Marlene D. Williams | Hairstylist |
| Directing | Peter Giuliano | First Assistant Director |
| Art | Greg John Callas | Construction Coordinator |
| Art | Rick Heinrichs | Set Designer |
| Art | Richard Hoffenberg | Construction Foreman |
| Art | Bill MacSems | Property Master |
| Crew | Ed Mirassou | Propmaker |
| Art | Nick Navarro | Set Designer |
| Art | Greg Papalia | Set Designer |
| Art | William A. Petrotta | Property Master |
| Sound | Steve Cantamessa | Boom Operator |
| Sound | Bruce Foster | Sound Editor |
| Sound | Richard Friedman | Supervising ADR Editor |
| Sound | David M. Ice | Sound Editor |
| Editing | Chris Jargo | Dialogue Editor |
| Sound | Fred Judkins | Supervising Sound Editor |
| Sound | Tom C. McCarthy | Supervising Sound Editor |
| Sound | Solange S. Schwalbe | Sound Editor |
| Sound | Don S. Walden | Sound Editor |
| Sound | Burton Weinstein | Sound Editor |
| Visual Effects | Pamela Easley | Visual Effects Coordinator |
| Visual Effects | Janet Healy | Visual Effects Producer |
| Crew | Jo Martin | Visual Effects Editor |
| Visual Effects | Dennis Muren | Visual Effects Supervisor |
| Crew | Joel Kramer | Stunt Coordinator |
| Camera | Robert Edesa | Camera Operator |
| Camera | Michael Genne | Camera Operator |
| Lighting | Leslie J. Kovacs | Chief Lighting Technician |
| Camera | Bruce McBroom | Still Photographer |
| Costume & Make-Up | Oda Groeschel | Costume Supervisor |
| Costume & Make-Up | G. Tony Scarano | Costume Supervisor |
| Sound | Peter Afterman | Music Supervisor |
| Directing | Faye Brenner | Script Supervisor |
| Production | Pamela Cederquist | Production Coordinator |
| Writing | Dan Aykroyd | Characters |
| Writing | Harold Ramis | Characters |
| Production | Dorothy O'Leary | Casting Assistant |
| Production | Bernie Brillstein | Executive Producer |
| Production | Joe Medjuck | Executive Producer |
| Production | Michael C. Gross | Executive Producer |
| Production | Sheldon Kahn | Associate Producer |
| Production | Gordon A. Webb | Associate Producer |
| Production | Gordon A. Webb | Unit Production Manager |
| Directing | Christine Larson-Nitzsche | Second Assistant Director |
| Directing | Michael D. Moore | Second Unit Director |
| Camera | Larry Hezzelwood | First Assistant Camera |
| Camera | Greg Walters | Second Assistant Camera |
| Camera | Tim Sasaki | Second Assistant Camera |
| Camera | Dylan Goss | Camera Loader |
| Art | John Warnke | Assistant Art Director |
| Art | Chuck McSorley | Leadman |
| Art | Jack Johnson | Production Illustrator |
| Art | Thom Enriquez | Production Illustrator |
| Art | Ann Harmon | Art Department Assistant |
| Art | Tom Miller | Assistant Property Master |
| Costume & Make-Up | Jennifer Butler | Costumer |
| Costume & Make-Up | Le Dawson | Costumer |
| Costume & Make-Up | Adrienne Manhan | Costumer |
| Camera | Gene Kearney | Key Grip |
| Lighting | Benny McNulty | Best Boy Electrician |
| Camera | Bob Munoz | Best Boy Grip |
| Lighting | Eric Smith | Electrician |
| Lighting | Ken W. Ballantine | Electrician |
| Lighting | E. Christopher Reed | Electrician |
| Lighting | Brent Poe | Electrician |
| Lighting | Gregory Peters | Electrician |
| Camera | Sandy Williams | Dolly Grip |
| Camera | Robert Sordal | Dolly Grip |
| Art | Francis N. 'Lucky' Costello | Standby Painter |
| Crew | Chuck Gaspar | Special Effects |
| Crew | Joe Day | Special Effects |
| Crew | Richard Wood | Special Effects |
| Sound | Gene S. Cantamessa | Production Sound Mixer |
| Crew | Mark Jennings | Cableman |
| Sound | Mark Gordon | Sound Editor |
| Sound | William Hartman | Sound Editor |
| Sound | Greig McRitchie | Orchestrator |
| Crew | Craig Pinkard | Transportation Coordinator |
| Crew | Dick Johnson | Transportation Captain |
| Directing | Ira S. Rosenstein | Second Second Assistant Director |
| Directing | Cyd Adams | Second Second Assistant Director |
| Production | Ginny Warner | Production Secretary |
| Production | Stuart Fink | Publicist |
| Production | Matthew Gould | Production Assistant |
| Production | Catherine Cederquist | Production Assistant |
| Production | Anne Prager | Production Assistant |
| Production | Stephanie Kahn | Production Assistant |
| Production | Gaetano Vaccaro | Production Assistant |
| Production | Jim Vatis | Production Assistant |
| Production | David Forbes | Production Assistant |
| Crew | Mary Peters | Stunts |
| Crew | Jon Curtis Price | Special Effects |
| Crew | Steven Lambert | Stunts |
| Costume & Make-Up | John Dods | Makeup Artist |
| Crew | Erik Cord | Stunts |
| Crew | Kurt Bryant | Stunts |
| Crew | Bob Minor | Stunts |
| Crew | Jophery C. Brown | Stunts |
| Art | Edmund E. Villa | Assistant Property Master |
| Crew | Tony Brubaker | Stunt Double |
| Crew | Gary J. Wayton | Stunt Double |
| Crew | Debbie Evans | Stunts |
| Crew | Andy Gill | Stunts |
| Crew | Billy D. Lucas | Stunts |
| Crew | Lane Leavitt | Stunts |
| Crew | Richard E. Butler | Stunts |
