Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
| Production | Margery Simkin | Casting |
| Art | Alex McDowell | Production Design |
| Production | Patrick Cassavetti | Producer |
| Production | Stephen Nemeth | Producer |
| Costume & Make-Up | Julie Weiss | Costume Design |
| Production | Laila Nabulsi | Producer |
| Editing | Lesley Walker | Editor |
| Art | Nancy Haigh | Set Decoration |
| Directing | Terry Gilliam | Director |
| Camera | Nicola Pecorini | Director of Photography |
| Art | Chris Gorak | Art Direction |
| Writing | Terry Gilliam | Screenplay |
| Production | Elliot Lewis Rosenblatt | Co-Producer |
| Crew | JoAnn Fregalette Jansen | Choreographer |
| Art | Ronald Day | Painter |
| Art | Lynn Christopher | Set Designer |
| Art | Mark Blumenthal | Standby Painter |
| Art | Mark Weissenfluh | Leadman |
| Camera | Frank Perl | Camera Operator |
| Art | Glen Hanz | Sculptor |
| Writing | Tod Davies | Screenplay |
| Writing | Tony Grisoni | Screenplay |
| Writing | Alex Cox | Screenplay |
| Production | Richard Foos | Executive Producer |
| Production | Harold Bronson | Executive Producer |
| Sound | Ray Cooper | Original Music Composer |
| Production | John Jergens | Associate Producer |
| Art | Dan Pemberton | Construction Coordinator |
| Camera | Łukasz Bielan | First Assistant Camera |
| Camera | Peter Mountain | Still Photographer |
| Lighting | Christopher Lyons | Gaffer |
| Visual Effects | Michael Cooper | Visual Effects Coordinator |
| Visual Effects | Kent Houston | Visual Effects Supervisor |
| Crew | Randy Benjamin | Picture Car Coordinator |
| Crew | Roanne Moore | Post Production Assistant |
| Crew | Maureen Kropf | Scenic Artist |
| Crew | Pat Stubbs | Transportation Co-Captain |
| Directing | Karon May | Script Supervisor |
| Costume & Make-Up | Linda S. Cormany | Set Costumer |
| Crew | Rob Bottin | Makeup Effects |
| Crew | Gloria M. Fujita | Set Medic |
| Crew | Steve Galich | Special Effects Coordinator |
| Editing | David Rees | Color Timer |
| Crew | Kelly Joe Dugan | Stunts |
| Sound | Peter Pennell | Supervising Sound Editor |
| Art | Tom Lifsey | Construction Foreman |
| Costume & Make-Up | Olga Ishkhanova | Seamstress |
| Production | Pearl A. Lucero | Production Coordinator |
| Crew | Ian Kelly | Video Assist Operator |
| Lighting | Reynaldo Barrera | Electrician |
| Production | Molly Allen | Location Manager |
| Production | Deborah Ricketts | Researcher |
| Sound | Jay Meagher | Production Sound Mixer |
| Costume & Make-Up | Kimberly Adams | Assistant Costume Designer |
| Costume & Make-Up | Bridget Cook | Hairstylist |
| Crew | James Lowder | Transportation Coordinator |
| Production | Mark Indig | Unit Production Manager |
| Visual Effects | Ray Svedin | Special Effects Supervisor |
| Art | Frank McEldowney | Greensman |
| Costume & Make-Up | Eden Clark Coblenz | Costume Supervisor |
| Camera | Nicola Pecorini | Steadicam Operator |
| Costume & Make-Up | Bill Fletcher | Wigmaker |
| Crew | Matt Langenbach | Stand In |
| Sound | Dominic Lester | Sound Re-Recording Mixer |
| Crew | Jimmy Bennett | Set Production Assistant |
| Art | Andrea Carter | Art Department Coordinator |
| Art | Tani Kunitake | Production Illustrator |
| Art | Dianne Chadwick | Art Department Assistant |
| Crew | Gary Gingold | Craft Service |
| Crew | Pedro Amaya | Driver |
| Crew | Michael Solinger | Post Production Supervisor |
| Crew | Earl F. Betts | Propmaker |
| Crew | Noon Orsatti | Stunt Coordinator |
| Crew | Michael Singer | Unit Publicist |
| Lighting | James Babineaux | Best Boy Electric |
| Sound | Randy Smith | Boom Operator |
| Sound | Kevin Lane | Music Editor |
| Art | Paige Augustine | Set Dresser |
| Costume & Make-Up | Cheryl Ann Nick | Key Makeup Artist |
| Camera | Peter Chrimes | Key Grip |
| Sound | Martin Cantwell | Assistant Sound Editor |
| Sound | David Acord | Utility Sound |
| Sound | Joe Gallagher | ADR Editor |
| Sound | Caroline Dale | Musician |
| Directing | Christina Fong | Second Assistant Director |
| Camera | Michael Mick Armstrong | Grip |
| Costume & Make-Up | Rebeka L. Roberts | Ager/Dyer |
| Costume & Make-Up | Lisa Rocco | Makeup Artist |
| Directing | Philip A. Patterson | First Assistant Director |
| Production | Nancy Restuccia | Assistant Production Coordinator |
| Costume & Make-Up | John Linsmeier | Key Costumer |
| Camera | Lila Byall | Camera Loader |
| Sound | Bob Risk | Foley Editor |
| Camera | Carlos M. Gallardo | Dolly Grip |
| Production | Carmen Cuba | Casting Assistant |
| Sound | Stephen Bridgewater | ADR Supervisor |
| Costume & Make-Up | Bryan Birge | Costumer |
| Directing | Bruce Logan | Second Unit Director |
| Art | P. Scott Bailey | Swing |
| Camera | Warren Feldman | Second Assistant Camera |
| Production | Kristen Felan | Payroll Accountant |
| Sound | J.R. Westen | ADR Mixer |
| Crew | Joe Barden | Special Effects Assistant |
| Crew | Jimmy Ortega | Stunt Double |
| Editing | Jeremy Hume | Assistant Editor |
| Production | Serena Baker | Location Assistant |
| Crew | Jose Gonzales | Catering |
| Production | Susan Giordano | First Assistant Accountant |
| Camera | Sonja Rom | Camera Production Assistant |
| Production | Keli Craig | Production Assistant |
| Production | Jenni Wieland | Second Assistant Accountant |
| Directing | Seth Edelstein | Second Second Assistant Director |
| Costume & Make-Up | Amy Gilliam | Wardrobe Assistant |
| Production | Alisa Moeller | Assistant Production Coordinator |
| Art | Martin Charles | Graphic Designer |
| Camera | Steve Itano | First Assistant "A" Camera |
| Crew | Sav Akyüz | Intern |
| Camera | Vidal Cohen | Best Boy Grip |
| Production | R. Scott Poole | Assistant Location Manager |
| Sound | Paul Carr | ADR Recordist |
| Sound | Alan Paley | Dialogue Editor |
| Art | Will Blount | Property Master |
| Crew | Ernie F. Orsatti | Stunts |
| Writing | Hunter S. Thompson | Novel |
