When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.
| Directing | Lawrence Guterman | Director |
| Writing | John Requa | Screenplay |
| Writing | Glenn Ficarra | Screenplay |
| Sound | John Debney | Original Music Composer |
| Production | Christopher DeFaria | Producer |
| Camera | Julio Macat | Director of Photography |
| Editing | Rick Finney | Editor |
| Visual Effects | Eric Oliver | Animation |
| Writing | Bob Camp | Storyboard |
| Crew | J.J. Makaro | Stunt Coordinator |
| Visual Effects | John Slattery | Digital Compositor |
| Visual Effects | Craig Barron | Visual Effects Supervisor |
| Sound | Mark A. Mangini | Supervising Dialogue Editor |
| Editing | Michael A. Stevenson | Editor |
| Art | James D. Bissell | Production Design |
| Costume & Make-Up | Tish Monaghan | Costume Design |
| Production | Andrew Lazar | Producer |
| Production | Craig Perry | Producer |
| Production | Warren Zide | Producer |
| Production | J.C. Spink | Executive Producer |
| Production | Chris Bender | Executive Producer |
| Production | Bruce Berman | Executive Producer |
| Visual Effects | Bill Westenhofer | Visual Effects Supervisor |
| Editing | Jason Tucker | First Assistant Editor |
